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The strongest data comes from Harshini Neelakantan, Stan Watowich, and colleagues at the University of Texas Medical Branch (UTMB)

Along with eyesight abnormalities, those who are vitamin B12 deficient may also suffer tingling or numbness in their hands and feet

This makes it suitable for individuals who do not need appetite control or cannot tolerate GLP-1 agonist side effects

Diagnosis of deficiency and insufficiency clinical and laboratory pitfalls , Critical Reviews in Clinical Laboratory Sciences, 58:6, 399-429, DOI: 10.1080/10408363.2021.1885339 Ankar A, Kumar A