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However, other researchers have argued that controversial issues exist because GPNA also inhibits other glutamine transporters, such as SLC38A1, and V-9302 is effective even in SLC1A5 knockout models 206,207

Investigating the molecular mechanisms involved in restoring the intracellular redox-buffer cysteine is of a great interest in the understanding of ferroptosis resistance mechanisms

Notably, the focus on healthy males may have limited the observation of significant biochemical changes, highlighting the need for further research in more diverse populations

Additionally, reports of potential toxic effects such as proteinuria and haematuria have also emerged (201)

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