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E.ChenL.ParkM.et al (2013)

Himeno A, Tsujikami M, Koizumi S, et al

In terms of NLRP3 inhibitors, tranilast, a clinically approved anti-allergic drug with additional anti-inflammatory effects inhibiting NLRP3 inflammasome activation by disrupting the mammalian NIMA-related kinase 7 (NEK7) interaction, 224,225 has been confirmed to exhibit significant preventive and therapeutic efficacy in mouse models of NLRP3 inflammasome-mediated human pathologies, e.g., gouty arthritis and type 2 diabetes