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It promotes neutrophil chemotaxis and degranulation leading to local inflammation in damaged tissues 37

The precipitated pellet was dissolved in 0.25 M acetic acid and dialysed in 17.4 mM acetic acid

Error bars and statistical tests are reported in the figure captions

We also review preclinical and clinical data for the activin receptor type IIA ligand traps sotatercept and luspatercept that have recently shown promising results in overcoming the myelosuppressive effects of TGF- signaling alterations to improve hematopoiesis in transfusion-dependent, non-del(5q) LR-MDS patients