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TB-500 protocol considerations Reported dosing in the research literature: Starting dose: 500 mcg daily, subcutaneous injection Titration: Increase by 100 to 150 mcg every two weeks as tolerated Target dose: 750 to 1000 mcg daily by weeks five through twelve Weekly total: Approximately 5 mg per week at full dose Cycle length: Eight to twelve weeks, with optional extension to sixteen weeks TB-500 is typically administered once daily via subcutaneous injection, with consistent timing and systematic site rotation

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Only then did the drug industry, and everyone else, change focus. A final hurdle came in 2009, once the drug had gotten to phase three of testing for FDA approval: Thirteen patients in the 1,200-person trial were found to have elevated liver enzyme counts