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Epub 2017 Mar 31

In Silico Studies of Bioactive Compounds From Hibiscus rosasinensis Against HER2 and ESR1 for Breast Cancer Treatment. International Journal of Pharmaceutical Sciences and Nanotechnology (IJPSN) 14, no

GPX4 activity and expression analysis In brief, 4T1 cells were seeded in 6-well plates and cultured for 12 h before use

This was evidenced by the prevention of IMP-induced ALDH3A1 upregulation by CH, and by the blockage of AHR-mediated ferroptosis inhibition by ALDH-IN (a specific ALDH3A1 inhibitor) via the Nrf2/HO-1/GPX4 axis, along with the attenuation of lung protection in both in vitro and in vivo models