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Medical conditions affecting absorption warrant particular attention : Pernicious anaemia : an autoimmune condition destroying gastric parietal cells, requiring lifelong B12 injections Gastrointestinal surgery : particularly gastric bypass, gastrectomy, or terminal ileum resection Inflammatory bowel disease : Crohn's disease affecting the terminal ileum impairs absorption Coeliac disease : untreated disease damages the small intestine, reducing B12 uptake Medication use : long-term metformin therapy (MHRA safety alert) or nitrous oxide exposure Symptoms suggesting possible B12 deficiency include : persistent fatigue, weakness, paraesthesia (pins and needles) in hands or feet, glossitis (sore, red tongue), mood changes, memory problems, or unexplained anaemia

Our top recommendations generally use ingredients in safe doses for most people

It also helps block DHT, a hormone associated with hair thinning

For the analysis of anti-GX-G3 antibodies, blood was collected from rats on weeks 0 (pre-dose), 2 (Day 14), 4 (Day 28), and 8 (Recovery day 29) and from monkeys on weeks 0 (Day 1), 1 (Day 8), 3 (Day 22), 4 (Day 29) and 8 (Recovery day 30)