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The researchers found that the elevated ROS level triggered by erastin can stimulate Nedd4 expression by inducing Forkhead Box M1 (FOXM1), an essential regulator for oxidative stress and cancer cell survival

The available data from in vitro experiments indicates that berberine demonstrates immunomodulatory properties by primarily activating macrophages and enhancing their Mtb -killing abilities, while simultaneously decreasing the expression of pro-inflammatory factors (Ozturk et al., 2021)

Arsenic binding induces a conformational change in the structure of the protein (PML-RARa), facilitating its oligomerization