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In vivo studies of the latter two revealed that the combination of both antibodies is recommended to achieve a reasonable increase in mean survival times after irradiation in rats bearing tumors expressing both isoforms (EGFR and ERGFRvIII) of the EGFR (Yang et al., 2009b)

These ROS not only potentially amplify the original hormone-induced growth signals by acting as secondary amplifiers, but may also create a microenvironment conducive to fibroid growth by serving as permissive factors through persistent low-level oxidative damage

R., Gagnon, L

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found that while macaques immunized with a modified vaccinia Ankara viral vector expressing the SARS-CoV S protein had reduced viral replication after challenge, anti-S IgG also enhanced pulmonary infiltration of inflammatory macrophages and resulted in more severe lung injury compared to unvaccinated animals 66