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Moreover, replacement of Cys10 with serine in a TTR-V30M-based mouse model has been shown to prevent amyloid formation [24]

doi: 10.3390/nu13114025 429 TuSHChenLCHoYS

Nature 520 , 5762 (2015)

Although this might be seen as a positive for increasing cysteine and glutathione, in fact it is thought that the excess of cystathionine is overall negative and could flood and impair the other pathways below, or specifically increase ammonia

Disruptions in iron metabolism lead to pathological conditions, with transferrin-Fe3+ complex formation occurring when transferrin binds external Fe3+ on the cell membrane, which is subsequently internalized by transferrin receptor 1 (24)