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The absorption process requires adequate stomach acid, intrinsic factor production, and healthy small intestine function

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Are B vitamin supplements safe for cancer patients to take during treatment

A randomized, double-blind, placebo-controlled trial in 191 older adults (75 years) with moderate vitamin B 12 deficiency (serum cobalamin concentrations of 107-210 pmol/L) without anemia provided participants with 1 mg/day of cyanocobalamin for one year (94)

Not because oral dosing is impossible, but because the compound's pharmacokinetic profile makes oral bioavailability unreliable for controlled studies