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Despite the presence of antioxidant agents within the lens (such as vitamins and antioxidant enzymes), OS is widely recognized as a major contributor to cataract development, alongside other environmental and endogenous factors [205,206,210,211]

Peran L, Sierra S, Comalada M, Lara-Villoslada F, Bailn E, Nieto A, Concha A, Olivares M, Zarzuelo A, Xaus J: A comparative study of the preventative effects exerted by two probiotics, Lactobacillus reuteri and Lactobacillus fermentum, in the trinitrobenzenesulfonic acid model of rat colitis

Furthermore, treatment of cells with 22(R)-diol and pregnenolone and ensuing oxidative stress resulted in decreased mRNA levels of StAR and CYP11A1 and increased mRNA levels of antioxidant enzymes SOD1, SOD2 and CAT