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EC heterogeneity revealed by scRNA-seq In addition to the well-known EndMT state of ECs, scRNA-seq has significantly advanced the understanding of EC heterogeneity in atherosclerosis by providing detailed insights into the diverse cellular phenotypes and functions within atherosclerotic lesions [22,102]

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It is worth noting that Fig.3 highlights four major issues affecting the effectiveness and safety of Se-based treatments: (1) a narrow therapeutic window requiring precise dosing to avoid toxicity or ineffectiveness