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1 Introduction 1.1 Bile acids: key immuno-metabolic signals sculpted by the gut microbiota Bile acids (BAs), beyond their traditional role in lipid digestion, are now recognized as pleiotropic signaling molecules crucial for metabolic and immune homeostasis ( 1.2 The tumor immune microenvironment and dysregulation of the microbiota-bile acid axis in cancer Before delving into the pathological consequences of a dysregulated microbiota-BA axis, it is important to first establish its fundamental role in maintaining homeostasis

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Ultrastructural analysis revealed morphological characteristics indicative of ferroptosis in the HG and erastin cell groups, such as mitochondrial contraction, increased membrane density and reduced or absent mitochondrial ridges (Fig

10.1161/circulationaha.118.038379 Circulation