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It plays roles in cell migration, inflammation regulation, wound healing, and angiogenesis

Canagliflozin (Cana), an anti-diabetes drug, also promotes the system Xc-/GPX4 axis to inhibit ferroptosis, attenuating cardiovascular diseases (Du et al

Additionally, the ELISA results demonstrated that both Fer-1 and QCT significantly alleviated the inflammatory and angiogenic imbalance

Sulforaphane selectively triggers apoptosis in GBM cells through activation of the ATF4CHOP axis [129], whereas the proteasome inhibitor marizomib upregulates ERS markers such as GRP78, IRE1, and CHOP to induce caspase-3-dependent apoptosis, independent of ROS and autophagy [130]