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In contrast, NAC, bearing a negative charge at physiological pH, demonstrates slower cellular uptake due to its N-acetyl group, which hinders both passive and active membrane transport

The cysteinyl sulfur of glutathione (GSH) is maintained in the reduced state by NADPH produced in the oxidative phase of the pentose phosphate shunt and provides a nucleophilic thiol important for the detoxification of electrophilic metabolites and metabolically-produced oxidizing agents

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[DOI] [PMC free article] [PubMed] [Google Scholar] 391.Hodi FS, ODay SJ, McDermott DF, Weber RW, Sosman JA, et al

The total duration of anesthesia was approximately 10 min, and injections were conducted at room temperature (22C)