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16 Some matrices also contain natural inhibitors that hinder the bioactivity of target analytes

Indeed, compared with current ferrotherapies that act mostly through delivery of exogenous iron or ferroptosis inducers, the strategy to induce cellular intrinsic ferrotosis outperforms them with lower systemic toxicity, increased cell selectivity and good biocompatibility 18

evaluated the anti-inflammatory effects of silymarin on cerulein-induced acute pancreatitis in mice and reported that silymarin (25 mg/kg, 50 mg/kg, and 100 mg/kg) weakened the severity of acute pancreatitis due to inhibition of p38 mitogen-activated protein kinase (MAPKs) and so it may be a drug for patients with pancreatitis (57)

Acta 89 MakarT

CON, control diet (0% MSM in diet)