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Goodwin RD, Kim JH, Weinberger AH, et al

Back to Basics: Iron Overload Unmasked Learning Objectives: In this Back to Basic post, the learner will be able to: 1

Nat Biomed Eng 8(5):593-610, 2024

53,73 The disulfide bond reduction and irreparable trimming of N -linked glycans generate degrons selectively modified with glycans such as Man 7 GlcNAc 2 , Man 6 GlcNAc 2 , or Man 5 GlcNAc 2 , which prevents substrate re-engagement with calnexin or calreticulin for nonproductive folding cycles