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Passive diffusion also occurs throughout the intestinal tract, allowing approximately 1% of oral doses to be absorbed without intrinsic factor

Gut Immune System-Epithelial Barrier Interplay The integrity of the IEB depends on the delicate balance between differentiation and renewal of intestinal epithelial cells, the response to signals coming from the lumen including microbiota and their end products, and nutritional factors introduced with daily diet as well as signals coming from the mucosal immune system (202)