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On the other hand, free radicals directly degrade the joint cartilage by targeting its proteoglycan and restricting its synthesis

The innate immune response is a first step to protecting against pathogens, which stimulate the interferon signaling pathway and expression of IFN-I, leading to an antiviral cellular response [51]

One study that followed 108,255 individuals for an average of 5.1 years found insomnia was associated with an increased risk of developing AMD (Tsai 2020)