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CBD, cannabidiol

The ability of this complex depends on ligand-induced activation of both the VDR and RXR, reflecting a dual-ligand requirement for effective transcriptional regulation ( Physiologically, vitamin D plays a central role in calciumphosphate homeostasis and bone metabolism

Subsequently, the sections were reacted with the following primary antibodies: NF-B (p65) (1:200, Santa Cruz, sc-8008), IL-6 (1:500, Bioss bs-0782R-TR), COX2 (1:200, Santa Cruz, sc-376861), BAX (1:100, Santa Cruz, sc-7480), Bcl-2 (1:200, Millipore, AB1722), GPx4 (1:100, Abcam, ab125066), and FACL4 (1:200, Abcam, ab155282) in blocking medium for 48 h at 4 C

Conversely, HIF-1-mediated hypoxic responses can affect cellular redox status and thus NRF2 activity [26]

Another study has identified four key ferroptosis-related genes that might be used as biomarkers for early diagnostics of ASD, although the diagnostic criteria for ASD based on these findings still need to be validated