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Under oxidative stress, cysteine residues on Keap1 are modified, leading to conformational changes that prevent effective promotion of Nrf2 degradation [37, 38]

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J Struct Funct Genom 16(2):5565 Ukkonen K, Mayer S, Vasala A, Neubauer P (2013) Use of slow glucose feeding as supporting carbon source in lactose autoinduction medium improves the robustness of protein expression at different aeration conditions

Materials and methods Laboratory animals All animal experiments were conducted in accordance with the EU Animal Experimentation Directive 2010/63/EU and the Association for Research in Vision and Ophthalmology (ARVO) guidelines

The IMS redox sensor in isolated mitochondria is accessible to exogenous GSH Our data so far indicated that the glutathione pools of the IMS and cytosol are connected