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doi: 10.1159/000083511

iNOS is essential to maintain a protective Th1/Th2 type of immune response via balanced production of proinflammatory and anti-inflammatory cytokine

Some treatments can take up to a year before any benefit is seen

Over time, a substantial proportion of patients develop a progressive phase, typically 10 to 15 years after disease onset, characterized by gradual accumulation of disability and ongoing neurodegeneration that becomes less directly associated with the acute inflammatory activity [104]