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A 30-minute chlorine gas challenge (184 ppm or 400 ppm) significantly induced hypoxemia and hypercapnia, increased BAL fluid protein concentration, and significantly decreased BAL fluid ascorbate levels in a rat model (Yadav et al., 2010)

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Future studies should investigate whether HIF stabilization directly modulates erythrocyte apoptotic pathways, such as by upregulating anti-apoptotic genes or downregulating pro-apoptotic factors

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This condition is often linked to lifestyle factors such as poor diet, obesity, and excessive alcohol consumption