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Wenzel J, Tting T

Li Y, Chu F, Li P, Johnson N, Li T, Wang Y

& Dinarello, C

The 2025 review by Sychowski and Cierniak in International Journal of Molecular Sciences the most recent comprehensive overview states explicitly that the mechanism of action remains unclear and that information on short- and long-term toxicity, genotoxicity, and carcinogenic potential is missing from the analysed literature, and would be required before any approval as an active pharmaceutical ingredient

In turn, inflammatory cytokines can regulate the release of substance P and expression of NK-1R by leukocytes, further sensitizing these cells to the effects of substance P in a positive feedback loop-like manner (Marriott and Bost, 2000