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A single-center, double-blind, randomized, placebo-controlled, two-arm study to evaluate the safety and efficacy of once-weekly sirolimus (rapamycin) on muscle strength and endurance in older adults following a 13-week exercise program

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Research demonstrates that senescent cells upregulate FOXO4 expression as a survival mechanism, using the transcription factor to sequester p53 in the nucleus and prevent its pro-apoptotic signaling cascade