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These beneficial effects may be due to the formation of detour circuitswhich encompass spared tissue surrounding the lesionand could reconnect locomotor circuits [69], thus enabling afferent inputs to be processed and conveyed to the cortex [73] and improving spinal reflexes, even below the injury [74]

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doi: 10.1016/j.envpol.2020.114129 111 MesnageRTeixeiraMMandrioliDFalcioniLDucarmonQRZwittinkRDet al

This longer window of action makes it a far more practical tool for a variety of research models