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While there arent currently many prescription medications that directly affect glutamate, there are several companies investigating its potential for treating severe treatment-resistant depression, substance abuse, and obsessive-compulsive disorder

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(38) conducted a parallel clinical trial assessing the effects of 2 g/day of extended release niacin, 4 g/day of omega-3 fatty acids, a combination of the two, or a respective dual placebo for 16 weeks on plasma lipids and lipoproteins in 56 adults with metabolic syndrome

N-acetylcysteine supports natural glutathione production inside cells, while vitamin C regenerates oxidized glutathione into its active antioxidant form