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Reports have demonstrated that -KG coordinates the M1/M2 phenotypic balance of alveolar macrophages via immune response modulators (PPAR or mTORC1), thereby impacting sepsis-associated ALI/ARDS (323)

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Thus, although it has to be demonstrated, Type IV pili binding to CD147 may alter intracellular lactate availability, providing the meningococcus with a local nutritional advantage