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Autoimmun Rev 17(10):10221027 Porta C, Paglino C, Mosca A (2014) Targeting PI3K/Akt/mTOR signaling in cancer

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In mammalian brain development, neural circuits go through an initial rapid increase in the number of synapses followed by a gradual decrease by selective elimination via microglia-mediated pruning (Paolicelli et al., 2011)