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Data availability The single-cell RNA-seq dataset generated during the current study is available in the NCBI Gene Expression Omnibus repository under the accession number GSE260946, The bulk RNA-seq dataset analyzed in this study is available in the NCBI Gene Expression Omnibus repository under the accession number GSE150365, References Emery, A

398, ISBN 0-12-181977-9

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Subgroup analysis by ethnicity revealed a significantly increased urinary system cancer risk for Caucasians and Indians (Caucasians: OR=1.16, 95%CI=1.05-1.27