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In a mouse model of diet-induced NASH, Notch signaling in hepatocytes induces osteopontin secretion, paracrine HSC activation and hepatic fibrosis, which are abrogated by Notch inhibition (132)

10.1016/j.coph.2007.04.004 Curr

While consuming a diet rich in Glutathione or taking supplements can increase the levels of Glutathione in the body, the efficacy of this antioxidant diminishes as it passes through the digestive system

Free radicals also deplete glutathione levels, increasing free radical damage and creating oxidative stress

Since it can bind to cells if the pO 2 levels are less than 10 mm Hg, Hypoxyprobe-1 is used as a probe for intracellular hypoxia detection