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The mechanism underlying colistin-induced nephrotoxicity is not fully understood, but it arguably initiates with extensive active reabsorption and accumulation of the drug in proximal tubular cells

98 : 441459 Miyazawa S, Ozasa H, Furuta S, Osumi T, Hashimoto T, Miura S et al

In such severe cases, cerebral oedema becomes clinically apparent 12 hours to 4 days after the overdose [18, 20, 50, 87], although CNS depression may be delayed if a slow-release preparation has been ingested [12, 50]

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Decker, who had been a teen phenomshe still holds three American recordswas then 37, and had just qualified for the 5K at the Atlanta Olympics