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Thus, LMW copper pool in the blood serum might be composed mainly from Cu(II)-His-Xaa complexes and can reach appr

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This sensitivity arises from the indole ring of Trp, which is characterized by a relatively large dipole moment both in the ground and excited states it extensively interacts with polar and charged groups in its environment, and whose photophysical properties are affected by surrounding residues, solvent exposure, and molecular motion (Lakowicz, 1983

Nelson DB, Rice DC, Niu J, Atay S, Vaporciyan AA, Antonoff M, Hofstetter WL, Walsh GL, Swisher SG , Roth JA, Tsao A, Gomez D, Giordano SH, Mehran R, Sepesi B