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Several A-binding anticalins with high affinities and specificities for the monomeric A peptide target have recently been described 23 , and their mode of tight complex formation with the central A epitope (Lys P16 to Lys P28 )which is common to both A 40 and A 42 peptide specieswas elucidated by X-ray crystallography 24

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These agents have demonstrated preclinical efficacy in reducing TMAO levels and mitigating cardiovascular risk, highlighting a potential avenue for precision microbiome-based therapy

However, they could be a possible alternative for men who cannot take certain medications or prefer a non-pharmaceutical approach