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Heterogeneity and clinical significance of ESR1 mutations in ER-positive metastatic breast cancer patients receiving fulvestrant

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Contact your GP or bariatric team promptly if you experience: Numbness that is worsening rather than gradually improving Numbness accompanied by significant leg pain, swelling, warmth, or redness (which may suggest DVT seek same-day assessment) Weakness in the leg or difficulty walking Numbness that extends beyond the thigh to involve the lower leg or foot Bladder or bowel changes alongside leg symptoms, or saddle anaesthesia (numbness in the groin, inner thighs, or buttocks), which may indicate cauda equina syndrome seek emergency assessment immediately Symptoms that begin or worsen several months after surgery, which may suggest a nutritional cause Call 999 or go to A&E immediately if you develop sudden breathlessness, pleuritic chest pain (sharp pain that worsens on breathing), or coughing up blood these may be signs of a pulmonary embolism (PE) , which is a medical emergency

TXNIP overexpression suppresses metformin-induced GLUT1 activation We next elucidated the effect of differential TXNIP expression on GLUT1 expression in IEC6 cells overexpressing TXNIP