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Description

One enzyme, CSE, supports the biosynthesis of persulfides, primarily by generating H 2 S from Cys, but potentially also by generating cysteine persulfide from cystine 14

These are all known drug targets

Notably, deletion of GPX4 caused severe phenotypic abnormalities in mice in animal experiments, whereas deletion of the ALOX12 gene did not cause major developmental defects in mice

GSHee could be an addition to the important strategy to mitigate OIRD via co-treatment with non-OR ventilatory stimulants that do not affect opioid-induced analgesia