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Cardiac cachexia is associated with reduced functional capacity [5] and decreased survival [1, 6]

Vitamin B12: The Energy and Metabolism Catalyst Vitamin B12 is crucial for red blood cell production, nerve function, and DNA synthesis

10.1016/j.amjcard.2020.05.045 39

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These prodrugs undergo cysteine-mediated transesterification 21 or aspecific esterase-catalyzed hydrolysis 20 , resulting in the release of H 2 S and the corresponding 5-thionucleoside