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Terminal ileum is the exclusive site for B12 absorption its inflammation or resection can cause profound megaloblastic anemia

As finalized, 427.201(a) establishes that CMS will use the methodology established in such section to calculate the inflation-adjusted beneficiary coinsurance and associated adjusted Medicare payment percentage and incorporates references to the existing provisions at 410.152(m), 419.41(e), and 489.30(b)(6)

These claims have yet to be evaluated in humans and there is no research showing that it has this effect in test subjects

Low B12s effect on blood is a specific type of anemia called megaloblastic anemia (as distinct from the more common iron deficiency anemia)

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