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112 DAN encompasses multiple subtypes, including cardiovascular autonomic neuropathy (CAN), gastrointestinal autonomic neuropathy, genitourinary autonomic neuropathy, sudomotor dysfunction, hypoglycemia unawareness, and pupillary dysfunction, each affecting different organ systems and presenting a spectrum of clinical manifestations

2 This subcutaneous chemical irritant activates peripheral nerves, leading to the activation of dorsal horn neurons

Almost all preterm infants develop seizures within the first 24 hours of life, while other affected infants usually develop seizures within the first week of life

D.ToomeyR.et al (2015)

You lose the synergistic pulse effect that makes the combination valuable