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Chronic GSH deficiency by Gclm deletion in mice has also been associated with metabolic alterations and the activation of the stress-responsive factor AMPK 53,84

Silence or correct mutations: e.g., SNCA and LRRK2 via RNA interference (RNAi) or CRISPR-Cas9 ( AAV2-based vectors have been used in clinical trials to deliver therapeutic genes to the striatum or SNpc, showing safety and moderate benefit ( 5.5 Stem cell-based approaches Stem cell therapies offer the potential to replace lost dopaminergic neurons and restore neural circuitry

doi: 10.3390/nu13010153 28

Vitamin K nutrition and bone health