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Disclosures: Nimmy Thomas: Nothing to Disclose, Christina Stull: Nothing to Disclose, Holli Sadler: Nothing to Disclose 1056 RISK OF INCIDENT EXTRAHEPATIC CANCERS AMONG MEDICARE PATIENTS WITH NON-ALCOHOLIC STEATOHEPATITIS (NASH) Jesse Fishman 1 Yestle Kim 1 Joe Medicis 1 Matthew Davis 2 Dominic Nunag 2 Robert Gish 3 , 1 Madrigal Pharmaceuticals, Inc., 2 Medicus Economics, LLC, 3 Robert G Gish Consultants LLC Background: NASH, or metabolic dysfunction-associated steatohepatitis (MASH), is a severe form of non-alcoholic fatty liver disease (NAFLD), or metabolic dysfunction-associated liver disease (MASLD)

Over time, membrane deformability declines due to changes in lipid content and oxidative damage to proteins (61, 62)