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Increased CDA expression/activity in males contributes to decreased cytidine analog half-life and likely contributes to worse outcomes with 5-azacytidine or decitabine therapy

In theory, a hyperoxidizing ER could preferentially sustain IRE1 and PERK activity, while preventing activation of ATF6

In a recent systematic review, a potentially beneficial effect of electrical stimulation (TENS, electroacupuncture, internal nerve stimulation) on POI was identified