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10.1161/circresaha.118.314665 37 DixonS

Xie Z, Chen F, Li WA, Geng X, Li C, Meng X, et al

The two reasons are that CBS is activated by estradiol and betaine (Bet), which is twice as high in females compared to males because the enzyme PEMT [Figure 1] is activated by a factor of 2.3 in menstruating females