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Third, translational gaps between preclinical models and clinical practice are prominent: most therapeutic candidates (e.g., natural products and repurposed drugs) have only been validated in rodent models, with limited data on human renal tissue responses, optimal dosing windows, or potential drugdrug interactions in clinical settings (e.g., in patients undergoing kidney transplantation or cardiovascular surgery)

M., Sajjakulnukit, P., Li, S., Crespo, J., Nwosu, Z

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214 The binding of PD-L1 to PD-1 inhibits T cell function by abrogating their capacity to detect and eliminate tumor cells, facilitating immune evasion

Additionally, our findings show that RW retained its polyphenol-derived antihyperglycemic properties