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Oxid Med Cell Longev 2021:112

They showed that IGF-1 delays the onset of behavioural symptoms and sustains life to a greater degree than GDNF

A recent study has examined the effect of cobalamin supplementation on the outcomes of treatment for feline patients with severe cobalamin deficiency and histories suggesting chronic gastrointestinal disease.5 In this study, serum concentrations of methylmalonic acid normalized following parenteral cobalamin supplementation, indicating that cobalamin deficiency was the cause of the high methylmalonic acid in serum

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These cytokines can reach the brain via systemic circulation, activating microglia and astrocytes and leading to neuroinflammatory responses (Erny et al., 2015)