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Disclosures: Tae-Hwi Schwantes-An: Target RWE: Consultant, Kung-Hung Lin: Nothing to Disclose, Marco Abreu: Nothing to Disclose, Jingyi Tan: Nothing to Disclose, Xiuqing Guo: Nothing to Disclose, Katherine Yates: Nothing to Disclose, Luca Lotta: Nothing to Disclose, Niek Verweij: Nothing to Disclose, Rohit Loomba: Eli Lilly and Company: Consultant, Jerome Rotter: Nothing to Disclose, Naga Chalasani: Madrigal: Consultant, Zydus, Ipsen, Pfizer, Merck, Altimmune, GSK: Consultant, Exact Sciences: Grant/Research Support, NIH: Grant/Research Support 2566 PATHOGENIC VARIANTS ASSOCIATED WITH MONOGENIC DISORDERS OF DYSLIPIDEMIA IN PATIENTS WITH WELL CHARACTERIZED MASLD Tae-Hwi Schwantes-An 1 Eduardo Vilar-Gomez 1 Marco Abreu 1 Brent Neuschwander-Tetri 2 Miriam Vos 3 Jian Wang 4 Xiuqing Guo 5 Jingyi Tan 5 Robert A Hegele 4 Nicholas Davidson 6 George Hindy 7 Luca Lotta 7 Niek Verweij 7 Jerome Rotter 5 Naga Chalasani 8 , 1 Indiana University School of Medicine, 2 Saint Louis University, 3 Emory University, Children's Healthcare of Atlanta, 4 Robarts Research Institute, 5 Lundquist Institute, 6 Washington University Medical Center, 7 Regeneron, 8 Indiana University Medical Center Background: Dyslipidemia is common in patients with MASLD, and it can sometimes be due to monogenic disorders

111 The regulation of the polarization state of macrophages affects their role in the inflammatory process, which regulates the immune response of the intestinal mucosa in UC

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The protectin family of specialized pro-resolving mediators: potent immunoresolvents enabling innovative approaches to target obesity and diabetes

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