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2020;6: e204564

Ionizing radiation can directly promote ROS production, which is a core component of its anti-tumor mechanism [266]

La Valle R, Wittenberg C: A role for the Swe1 checkpoint kinase during filamentous growth of Saccharomyces cerevisiae

Although Nrf2 is a master regulator of cellular redox homeostasis following stress, Nrf2 activity in vascular and other cell types is known to decline [131] and could play an important role in age-related cellular dysfunction and disease onset