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SAM is the universal methyl donor for DNA methylation, histone methylation, and hundreds of other methylation reactions that regulate gene expression

This anti-lipogenic activity is hypothesized to involve inhibition of acetyl-CoA carboxylase, the rate-limiting enzyme in de novo lipogenesis

Cycle structure: the common research community cycle is 8 to 12 weeks on, then 4 to 6 weeks off

Improved mood and cognitive function are also notable benefits, making handling stress easier and maintaining mental clarity