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(4) Albanese A, Bhatia K, Bressman SB, Delong MR, Fahn S, Fung VS, et al

Long-term use can worsen this side effect as the body becomes less responsive to this drug

Dual role of 3-methyladenine in modulation of autophagy via different temporal patterns of inhibition on class I and III phosphoinositide 3-kinase

Confounders including dietary Trp/I3C intake and host genetics are critically addressed: a Trp-rich diet potentiates I3A-mediated antitumor effects by increasing intratumoral I3A concentrations, but requires standardized dietary assessment in clinical trials (113)

However, it should be noted that both of these trials were conducted on a small sample size and further large-scale clinical trials are needed to provide more information on the clinical relevance of these treatments